ACUTE DERMAL TOXICITY OF COAL FLY ASH NANOPARTICLES IN VIVO
Keywords:Coal fly ash nanoparticles, Dermal toxicity, Histopathology
Objectives: To study the toxicity effects of coal fly ash nanoparticles-induced acute dermal toxicity in Wistar albino rats.
Methods: Acute dermal toxicity studies for coal fly ash nanoparticles (CFA-NPs) were conducted in Wistar albino rats. A single dose of various concentrations of CFA-NPs or vehicle was applied on the dorsal layer after shaving. Animals were observed for 14 days. Parameters like body weight, feed intake and histopathology were studied.
Results: The CFA-NPs treated rats did not show any abnormal clinical signs. The body weight was not significantly altered when compared with the control group. Treatment with CFA-NPs showed mild to severe histological changes in all organs with increase dose-related manner in concentrations of CFA-NPs treated groups. The acute dermal LD50 of CFA-NPs was found to be greater than 2000 mg/kg body weight (bw) for rats.
Conclusion: Dermal acute treatment with CFA-NPs can induce mild to significant dose-dependent histological changes in biological organs.
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