ACUTE DERMAL TOXICITY OF COAL FLY ASH NANOPARTICLES IN VIVO

Authors

  • Bharathi Sambandam Centre for Nanoscience and Technology, Anna University, Chennai 600025, India
  • Durga Mohan Centre for Nanoscience and Technology, Anna University, Chennai 600025, India
  • Pazhanivel Kaliyaperumal Department of Mechanical Engineering, Thiruvalluvar College of Engineering and technology, Arunachala City, Vandavasi 604505, India
  • Pachaiappan Raman Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, India
  • Devasena Thiyagarajan Centre for Nanoscience and Technology, Anna University, Chennai 600025, India

Keywords:

Coal fly ash nanoparticles, Dermal toxicity, Histopathology

Abstract

Objectives: To study the toxicity effects of coal fly ash nanoparticles-induced acute dermal toxicity in Wistar albino rats.

Methods: Acute dermal toxicity studies for coal fly ash nanoparticles (CFA-NPs) were conducted in Wistar albino rats. A single dose of various concentrations of CFA-NPs or vehicle was applied on the dorsal layer after shaving. Animals were observed for 14 days. Parameters like body weight, feed intake and histopathology were studied.

Results: The CFA-NPs treated rats did not show any abnormal clinical signs. The body weight was not significantly altered when compared with the control group. Treatment with CFA-NPs showed mild to severe histological changes in all organs with increase dose-related manner in concentrations of CFA-NPs treated groups. The acute dermal LD50 of CFA-NPs was found to be greater than 2000 mg/kg body weight (bw) for rats.

Conclusion: Dermal acute treatment with CFA-NPs can induce mild to significant dose-dependent histological changes in biological organs.

 

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Author Biographies

Bharathi Sambandam, Centre for Nanoscience and Technology, Anna University, Chennai 600025, India

Centre for Nanoscience and Technology

Durga Mohan, Centre for Nanoscience and Technology, Anna University, Chennai 600025, India

Centre for Nanoscience and Technology

Pazhanivel Kaliyaperumal, Department of Mechanical Engineering, Thiruvalluvar College of Engineering and technology, Arunachala City, Vandavasi 604505, India

Department of Mechanical Engineering

Pachaiappan Raman, Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603203, India

Department of Biotechnology

Devasena Thiyagarajan, Centre for Nanoscience and Technology, Anna University, Chennai 600025, India

Centre for Nanoscience and Technology

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Published

01-07-2015

How to Cite

Sambandam, B., D. Mohan, P. Kaliyaperumal, P. Raman, and D. Thiyagarajan. “ACUTE DERMAL TOXICITY OF COAL FLY ASH NANOPARTICLES IN VIVO”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 403-7, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/6447.

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