BIOACTIVITY GUIDED FRACTIONATION AND ANTI-INFLAMMATORY ACTIVITY OF ACACIA NILOTICA PODS

Authors

  • Khan Tabassum A. SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India
  • Anjaria Jeet K. SVKM’s School of Pharmacy and Technology, NMIMS University, Mumbai, India
  • Dedhia Vanish SVKM’s School of Pharmacy and Technology, NMIMS University, Mumbai, India
  • Gohel Anjali K SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India

Keywords:

Acacia nilotica, Anti-inflammatory, Phenolics and HPTLC

Abstract

Objective: The present study aims at screening the methanol extract and the tannin fraction of the pods of Acacia nilotica for anti-inflammatory activity.

Methods: The methanol extract and its tannin fraction were evaluated for acute toxicity using rats as per the Organization for Economic Co-operation and Development (OECD) guidelines. They were found to be safe up to a dose of 2000 mg/kg. The anti-inflammatory activity of the extract and its fraction was evaluated using the carrageenan-induced rat paw edema method for determining the acute phase of inflammation. The activity against sub-acute inflammation was evaluated using the cotton pellet granuloma pouch method. Diclofenac sodium was used as the reference drug.

Results: The results of pharmacological screening indicated the methanol extract to possess statistically significant anti-inflammatory activity at 100 mg/kg dose. The tannin fraction of methanol extract was found to be more potent than the methanol extract with maximum response at 25 mg/kg dose.

Conclusion: The methanol extract and tannin fraction of pods of Acacia nilotica possess significant anti-inflammatory activity the latter one being more potent.

 

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Author Biography

Khan Tabassum A., SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, India

Associate Professor,

Department of pharmaceutical chemistry

 

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Published

01-07-2015

How to Cite

A., K. T., A. J. K., D. Vanish, and G. A. K. “BIOACTIVITY GUIDED FRACTIONATION AND ANTI-INFLAMMATORY ACTIVITY OF ACACIA NILOTICA PODS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 7, July 2015, pp. 380-3, https://www.innovareacademics.in/journals/index.php/ijpps/article/view/6450.

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