IMPACT OF GERANIOL ON CYCLOPHOSPHAMIDE PROVOKED CARDIOTOXIC PROPERTIESâ€“AN IN VIVO STUDY
Keywords:Cyclophosphamide, Geraniol, Cardiotoxicity
Objective: Toxicity profiles of diverse anti-neoplastic drugs are extensively documented in past decades and the protective role of natural products against such toxic drugs plays a vital role in the evolution of chemoprevention. Globally, Cyclophosphamide (CYP) is used as an anticancer drug, but now it has been limited due to its acute and chronic cardio toxicity. Hence the present study was designed to investigate the protective role of Geraniol (GOH) against CYP induced cardio toxicity.
Methods: The activity of serum marker enzymes and lipoprotein fractions, cardiac marker enzymes and lipid profiles as well as antioxidant status was done using standard procedures in vivo. In addition, optimum dosage of GOH was determined as obtained by the levels of serum marker enzymes for tissue damage and the pathological changes were assessed by histology.
Results: Administration of CYP to rats results in hoisted levels of marker enzymes (in both serum and heart tissue) and reduced levels of antioxidants. GOH (200 mg/kg body weight) restrained the elevation of marker enzymes (in both serum and heart tissue) and augmented the levels of antioxidants. Moreover, histological observations added proofs to the protective role of GOH against cardiac damage.
Conclusion: CYP administered pathological changes were attenuated by the oral treatment of GOH at a dose of 200 mg/kg body weight of rat and suggests that the cardioprotective effects could be related to up regulation of antioxidant mechanism. Conclusive outcome from our findings suggests that GOH might be a potential chemo preventive agent in attenuating drug induced cardio toxicity.
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