ASSESSMENT OF THE TABLETING CHARACTERISTICS OF A NOVEL SORBITOL AND CALCIUM DIPHOSPHATE COMPOSITES
Keywords:Sorbitol, Calcium diphosphate, Composites, Tableting, Direct compression
Objective: To improve the tableting properties of sorbitol (SOR) via particle engineering through agglomeration with anhydrous calcium diphosphate (ACD) employing a house-made agglomerator.
Methods: A novel SOR: ACD composites were produced by agglomeration at the 95:5; 80:20, 50:50, 20:80 and 6:94 SOR to ACD. The resulting tableting properties such as densification, compressibility, compactibility, ejection force, elastic recovery, sensitivity to lubricants, compression speed and disintegration time were then evaluated.
Results: The new agglomerated excipient had better flow, compressibility and compactibility than the physical mixture of SOR and ACD being the 95:5 SOR: ACD ratio the composite that exhibited the best tableting properties.
Conclusion: This novel excipient has a potential use as a pharmaceutical aid for direct compression applications.
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