• Mirela MIRACI Faculty of Pharmacy, University of Medicine, Tirana, Albania
  • Arlinda Demeti Albanian Order of Pharmacists
  • Zamira Ylli University of Medicine
  • Suela KELLICI University of Medicine
  • Dhurata Tarifa Univerity Hospital Center ¨Mother Theresa


Biphosphonates, Osteoporosis, Alendronate, Tirana


Objective: Biphosphonates are well known drugs for their efficacy in reducing fracture incidence, increasing bone density and improving bone micro architecture. The aim of this study is to evaluate the effectiveness of ibandronate and alendronate used in the treatment of osteoporosis in post-menopausal women over the age of 50 y at a specialized clinic in Tirana and to calculate the annual cost of osteoporosis treatment and perform a cost-effectiveness analysis.

Methods: Study design: Retrospective study The patients included were all female, in menopause or post-menopause with T-score-1 to-6, treated with alendronate or ibandronate. The effectiveness of the treatment was calculated as the average percentage of change in bone mineral density (av. % of change in BMD) between 2011 and 2010 (baseline). The annual cost of the osteoporosis treatment according to the protocols and the cost of the DXA (dual x-ray absorptiometry) scan were calculated and the comparison of cost-effectiveness was performed.

Results: Patients with osteoporosis treated with ibandronate (n=24) had a statistically significant higher average change from baseline compared to patients treated with alendronate (n=46) (Mann Whitney U = 66.0, p<0.01). The annual cost of treatment with ibandronate was 1.3 times higher than that of alendronate.

The cost/efficacy ratio was 13.434 units for ibandronate and 31.677 units for alendronate type A1.

Conclusion: Ibandronate is more effective and cost-effective than alendronate in the treatment of osteoporosis.



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How to Cite

MIRACI, M., A. Demeti, Z. Ylli, S. KELLICI, and D. Tarifa. “THE COST-EFFECTIVENESS OF IBANDRONATE AND ALENDRONATE FOR THE TREATMENT OF OSTEOPOROSIS IN A SPECIALIZED CLINIC IN TIRANA”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 7, no. 11, Oct. 2015, pp. 207-11,



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