@article{El-hodairy_2014, title={NEUROPROTECTIVE EFFECTS OF PIMPINELLA ANISUM ON NORMAL AND DIABEITC RATS}, volume={6}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/4513}, abstractNote={<p><strong>Objective: </strong>Bisphenol A (BPA) was a polycarbonate plastic used in plastic containers, baby’s bottle, water bottles, laptops, mobiles, and food canes, etc. It is associated with obesity and insulin resistance. The food and Drug Administration (FAD), The Environmental Protection Agency (EPA) and the Occupational Safety and Health Administration (OSHA) recommended more study on this material. Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Diabetes can cause many complications like cardiovascular risk, chronic renal failure, nephropathy etc. The present study was done to know how to decrease the toxic effect of BPA by <em>Pimpinella anisum</em> (Anise) on the physiological and neurological parameter on normal and diabetic rats induced by Streptozetocin (STZ).</p><p><strong>Methods: </strong>Rats involved in this study were divided into eight groups: 1<sup>st</sup> control group and received citrate buffer, 2<sup>nd</sup> diabetic group treated with STZ (50mg/kg. b. wt), 3<sup>rd</sup> BPA group treated with BPA (30mg/kgbwt), 4<sup>th</sup> Anise group treated with anise oil. (3g/kgb. wt),5<sup>th</sup> STZ + BPA group combination between STZ and BPA with the same dose, 6<sup>th</sup> group treated with (STZ+Anise), 7<sup>th</sup> group treated with (STZ + Anise + BPA) and 8<sup>th</sup> group received Anise and BPA. All control and treatment were subsisted one month ago. Norepinephrine (NE), Dopamine DA and Serotonin (5HT) were determined in homogenate brain tissue by HPLC.</p><p><strong>Results: </strong>The results showed the significant increase in NE, DA and 5HT in diabetic rats treated with (STZ), and in diabetic rats with BPA (STZ + BPA) in comparison with vehicle and diabetic (STZ) group. The results also showed a significant increase in glucose, triglyceride, cholesterol, ALT and AST. After treatment with (Anis), a significant decrease in NE, DOP and 5HT in diabetic rats treated with Anise (STZ + Anise) and diabetic rats treated with (Anise + BPA) in comparison with vehicle and diabetic (STZ) group. Thus, from this study,</p><p><strong>Conclusion: </strong>It is concluded that, (BPA) has neurotoxic and this neurotoxicity was increased with diabetes and decreased by the treatment with anise.</p>}, number={12}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={El-hodairy, Fawkyeia A.}, year={2014}, month={Dec.}, pages={9–12} }