@article{V_R_Mukherjee_N_K_2015, title={HOMOCASTASTERONE: A NOVEL PLANT KETOSTEROID INDUCING HAEMATOLOGICAL CHANGES IN NORMAL AND DIABETIC MALE RAT}, volume={7}, url={https://journals.innovareacademics.in/index.php/ijpps/article/view/5980}, abstractNote={<p><strong>Objective: </strong>To study the effect of brassinosteroid keto isoform homocastasterone, in diabetic male wistar rat as an antihyperglycemic factor and to evaluate its effects on the hemodynamic parameters in rat blood.</p><p><strong>Methods: </strong>Diabetes was induced in a group (n=6) of rats with a single peritoneal injection of streptozotocin at 60 mg/kg. bw. With a treatment schedule of 15 consecutive days, control (n=6) and diabetic rats received 666µg/kg bw, of homocastasterone. Circulating blood glucose, cell count, cell indices, and MDA level was assessed.</p><p><strong>Results: </strong>Significant reduction (p<0.05) in blood glucose level and increase inRBCs, WBCs, granulocytes, lymphocytes, monocytes and platelets count(p<0.05) along with improved functional indices for HCT, PCV, MCV, MCH, MCHC, MPV, PDW, PCT in homocastasterone treated diabetic group was noted. A significant reduction in RBC-MDA level (p<0.001) in the treated group was noted.</p><p><strong>Conclusion: </strong>It is suggested that brassinosteroid keto isoform homocastasterone exhibits antiglycemic effect in diabetic rat, and improves RBC, WBC, Platelet counts, haemoglobin level, and cell indices, while reducing peroxidative cell damage in RBCs.</p><p> </p>}, number={7}, journal={International Journal of Pharmacy and Pharmaceutical Sciences}, author={V, Athithan and R, Premalatha and Mukherjee, Victor and N, Mani and K, Srikumar}, year={2015}, month={Jul.}, pages={125–128} }