TY - JOUR AU - Kandale, Ajit AU - Ohlyan, Renu AU - Kumar, Ganesh PY - 2014/07/01 Y2 - 2024/03/29 TI - SYNTHESIS AND IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF 2, 3-ARYL SUBSTITUTED 1, 3-BENZOXAZIN-4-ONE DERIVATIVES JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 6 IS - 7 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/1198 SP - 68-71 AB - <p><strong>Objective:</strong> The aim of the present work was to design and synthesize 2, 3-aryl substituted 1, 3-benzoxazin-4-one derivatives and evaluate them for <em>in-vitro</em> antiproliferative activity against human breast adeno-carcinoma cells.</p><p><strong>Methods:</strong> The compounds were synthesized and screened for <em>in-vitro</em> antiproliferative activity against MCF-7 cell lines using 96 well plate method.</p><p><strong>Results:</strong> 3 out of 9 synthesized compounds showed good <em>in-vitro</em> inhibition of MCF-7 cell lines. Compound 2 showed least IC<sub>50 </sub>(highest active) i.e. 0.89 µg followed by compound 4 (IC<sub>50</sub>= 1.02 µg) and compound 3 (IC<sub>50</sub>= 1.19 µg). 4 compounds showed more than 90 % inhibition at 100 µg after 48 h incubation.</p><p><strong>Conclusion: </strong>This class of compounds showed some initial promising activity which can be further expanded by synthesizing and testing more analogs of this kind against MCF-7 cell lines which may give good leads to proceed.</p> ER -