TY - JOUR AU - Vinothkanna, Annadurai AU - Mariappan, Subbiah AU - Sekar, Soundarapandian PY - 2014/09/01 Y2 - 2024/03/29 TI - TRACKING THE ORGANOLEPTIC AND BIOCHEMICAL CHANGES IN THE AYURVEDIC POLYHERBAL AND NATIVE FERMENTED TRADITIONAL MEDICINES: BALARISHTA AND CHANDANASAVA JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 6 IS - 9 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/2600 SP - 521-526 AB - <p><strong>Objective: </strong>Ayurvedic formulary contains fermented polyherbal medicines which includes <em>Balarishta</em> and <em>Chandanasava. </em>The changes occurring in the successive stages of fermentation of these medicines are least understood such as organoleptic and biochemical parameters.<strong></strong></p><p><strong>Methods: </strong>The samples were collected from a manufacturing unit. The sensory evalution of color, smell, touch and taste was carried out. Biochemical estimations, GC-MS analysis, estimation of aflatoxins and heavy metals were performed.<strong></strong></p><p><strong>Results: </strong>The native fermentation led to browning with herbal odouration and sour taste in both <em>Balarishta</em> and <em>Chandanasava</em> preparations. pH was drastically reduced to acidic in <em>Balarishta</em> when compared to <em>Chandanasava</em>. Total solids drastically reduced in <em>Chandanasava</em> than in <em>Balarishta</em>. In both medicament fermentations, total sugar gradually decreased with concomitant increase in ethanol. Formation of acetic acid, gradual decrease in aminoacid and starch contents signify the fermentation process. Both <em>Balarishta</em> and <em>Chandanasava</em> were devoid of methanol, aflatoxins and heavy metals like mercury, lead and cadmium.<strong></strong></p><p><strong>Conclusion: </strong>Preparation of Ayurvedic fermented medicines exemplified by <em>Balarishta </em>and <em>Chandanasava </em>are earmarked with major changes in organoleptic and biochemical parameters and are found safe by the absence of toxic components assessed. <strong></strong></p><p> </p> ER -