TY - JOUR AU - Silnikov, Vladimir AU - Plotnikov, Evgenii AU - Plotnikov, Vladimir PY - 2015/06/01 Y2 - 2024/03/29 TI - PHARMACOKINETIC STUDIES OF NEW SILVER-BASED COMPLEX JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 7 IS - 6 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/5396 SP - 41-43 AB - <p><strong>Objective: </strong>Investigation of pharmacokinetics parameters of the new silver-based compound of general formula C<sub>6</sub>H<sub>19</sub>Ag<sub>2</sub>N<sub>4</sub>LiO<sub>6</sub>S<sub>2</sub>, called Argosil”, with high antiviral activity.</p><p><strong>Methods: </strong>Water solution of complex administered intragastrically in the dose rate of 100 mg/kg body weight of mice BALB/c (males) aged 1.5-2.0 mo. Blood and tissues samples analyzed by mass spectrometry.</p><p><strong>Results: </strong>Half-life of the drug was about 4 h at the initial stage. About 5% of the initially introduced silver detected after 24 h. Maximum drug concentration observed in the lung tissues.</p><p><strong>Conclusion: </strong>Results make the basis for further test and clinical implementation. Taken into account low toxicity and antiviral properties of this compound, it looks especially effective for lung infections treatment.</p><p> </p> ER -