TY - JOUR AU - Mahajan, Deepali C. AU - Satyapal, Usha S. AU - Tatke, Pratima A. AU - Naharwar, Vikram A. PY - 2015/07/01 Y2 - 2024/03/28 TI - EVALUATION OF PUNICA GRANATUM FRUIT PEELS EXTRACTS FOR ITS FREE RADICAL SCAVENGING AND ANTI-INFLAMMATORY ACTIVITY JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 7 IS - 7 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/6104 SP - 222-225 AB - <p><strong>Objective: </strong>To evaluate free radical scavenging and anti-inflammatory activity of petroleum ether, ethyl acetate, aqueous, methanol:water and methanol extracts of <em>Punica granatum</em> fruit peels (PGFP) (Family: Lythraceae) by <em>in vitro </em>methods.</p><p><strong>Methods: </strong>The free radical scavenging effect was studied using 1,1‐Diphenyl‐2‐Picrylhydrazyl (DPPH) and nitric oxide radical scavenging assay. Anti‐inflammatory activity was evaluated by HRBC membrane stabilization assay.</p><p><strong>Results: </strong>All the extracts of PGFP exhibited significant free radical scavenging effect. The methanol extract exhibited maximum significant DPPH and nitric oxide radical scavenging activity with IC<sub>50 </sub>value of 24.43 and 45.56µg/ml and maximum stabilization (86.96%) of HRBC membrane at 80 µg/ml among all the extracts of PGFP.</p><p><strong>Conclusion: </strong>Methanol as an extraction solvent was found to be the best in obtaining the extract of PGFP rich in radical scavenging and anti-inflammatory phytoconsituents.</p><p> </p> ER -