TY - JOUR AU - Sati, Nitin AU - Singh, Rajendra AU - Dahiya, Randhir AU - Singh, Pratap AU - Sati, Om Prakash PY - 2015/07/01 Y2 - 2024/03/29 TI - ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF RIBES GLACIALE WALL EXTRACTS JF - International Journal of Pharmacy and Pharmaceutical Sciences JA - Int J Pharm Pharm Sci VL - 7 IS - 7 SE - Original Article(s) DO - UR - https://journals.innovareacademics.in/index.php/ijpps/article/view/6500 SP - 344-347 AB - <p><strong>Objective: </strong><em>Ribes glaciale </em>Wall. is used in folk medicine by the locals of North West Himalayas, Uttarakhand, India, but its pharmacological potentials are not well studied. This work evaluates antioxidant, anti-inflammatory and analgesic activity of the extract of <em>Ribes glaciale</em> Wall.</p><p><strong>Methods: </strong>Antioxidant activity was assessed by studying free radical scavenging ability, total antioxidant capacity, ferrous ion chelation and reducing power of the extracts. The anti-inflammatory and analgesic activity was assessed by carrageenan induced rat paw edema and acetic acid induced writhing model respectively.</p><p><strong>Results: </strong>The methanolic and ethyl acetate extracts of <em>Ribes glaciale</em> Wall. Consists considerable amount of total phenolic and flavonoid contents. The ethyl acetate extract was potent in scavenging DPPH free radical (IC<sub>50</sub> 55.7 μg/ml) while methanolic extract demonstrated higher ability to scavenge ABTS free radical (TEAC 11802.2). Methanolic extract exhibited higher ferrous ion chelation activity (61% at 400 µg/ml). The ethyl acetate extract demonstrated superior reducing power and total antioxidant capacity. The methanolic extract was evaluated for anti-inflammatory and analgesic activity. Administration of methanolic extract of <em>Ribes glaciale</em> exhibited dose dependent inhibition of paw edema induced by carrageenan and also showed significant reduction in number of acetic acid induced abdominal writhing.</p><p><strong>Conclusion: </strong>The study revealed antioxidant potential of methanolic and ethyl acetate extract of <em>Ribes glaciale</em> Wall. The methanolic extract exhibited significant anti-inflammatory and analgesic activity and indicate the need for its further phytochemical evaluation.</p><p> </p> ER -