International Journal of Pharmacy and Pharmaceutical Sciences <div align="justify"> <div align="justify"> <p>International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is a monthly (April 2014 onwards) peer-reviewed, open access journal. IJPPS publishes original research work in the form of original articles or short communications, which contribute significantly to advance scientific knowledge in pharmacy and pharmaceutical sciences. Review articles on the current and trending subject are also considered by the journal provided they match the current research needs and possess scientific impact.</p> <p>The Scope of the journal encompasses the following</p> <ul> <li class="show">Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics</li> <li class="show">Pharmacognosy and Natural Product Research</li> <li class="show">Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis</li> <li class="show">Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy</li> <li class="show">Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics</li> </ul> <p>Research outcomes from medical science/case study and biotechnology of pharmaceutical interest are also considered. From March 2016 journal has also started considering hypothesis however the frequency is limited.</p> <p>IJPPS is committed to bring on surface the diligent and hard work of researchers for the betterment of science and society.</p> <br><br></div> </div> en-US (Editor) (Anchal) Mon, 01 Aug 2022 12:18:27 +0530 OJS 60 THERAPEUTICS APPROACHES OF INVERTEBRATE ANIMAL TOXINS: A REVIEW <p><em>The present review article</em> describes invertebrate venoms and various toxins secreted by them. Animal venoms are stores of novel peptides which exhibit a wide variety of biological effects and actively interact with pathogen and parasites. Animal toxins selectively bind to ion channels and receptors and display show hemolytic, <em>cytolytic</em><em>,</em> proteolytic, anti-diabetic, antimicrobial and analgesic activity. These generate allergic and inflammatory responses in victims. These disrupt cell membrane and inhibit bacterial growth and kill them. Animal toxins inhibit virus entry into host cells, and obstruct virus replication. These were also found highly effective against protozoan, and fungal pathogens. By using bio-informatics tools, methods and approaches, both structural and functional diversity of toxin peptides could be harnessed to develop highly effective broad spectrum drugs for therapeutics. Animal venoms are inexhaustible source of bioactive molecules, which could be used for development of immune diagnostics, various pharmaceuticals for therapeutics and bio-insecticides. Present article tries to explore exceptional specificity and high potency of animal toxins for drug development.</p> SIMRAN SHARMA, RAVI KANT UPADHYAY Copyright (c) 2022 SIMRAN SHARMA, RAVI KANT UPADHYAY Thu, 04 Aug 2022 00:00:00 +0530 CENTIPEDE VENOM TOXINS AND ITS BIOMEDICAL AND PHARMACOLOGICAL PROPERTIES <p>The present review article explains venoms from various centipede species with their biomedical and pharmacological properties. Centipede venom is a natural source of bioactive proteins, peptides and other small molecules. These use venoms as defense arsenals to paralyze prey. This review paper sketch out important physiological effects like platelet aggregation, anticoagulant, phospholipase A2 and trypsin inhibiting activity. Centipede venom toxins selectively bind Kv2.1 channel and block them. Centipede venom disrupts cardiovascular, respiratory, muscular and nervous systems by targeting the broadly distributed KCNQ channels. It also signifies toxin-voltage-gated integrations and its inhibition. These peptides can be used for developing drugs for treatments as well as bio-insecticides for agrochemical.</p> NIDHI YADAV, RAVI KANT UPADHYAY Copyright (c) 2022 RAVI KANT UPADHYAY, NIDHI YADAV Sat, 23 Jul 2022 00:00:00 +0530 PHYTOCHEMICAL SCREENING AND IN VITRO ANTIMICROBIAL AND ANTIFUNGAL ACTIVITY OF BERGENIA LIGULATA (WALL.) LEAVES EXTRACTS <p><strong>Objective: </strong>Evaluation of Antimicrobial and Antifungal potential of Phytoconstituents present in leaf extracts of <em>Bergenia ligulata (wall.) </em>plant.</p> <p><strong>Methods: </strong>The antimicrobial effects of leaves of <em>Bergenia ligulata</em> (wall.) were evaluated using both ethanol and aqueous extracts against <em>Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans,</em> and <em>Penicillium spp.</em> Agar well diffusion method was employed in determining the antimicrobial activity and the broth dilution method for determining the Minimum Inhibitory Concentration. All the isolates examined were susceptible to both the ethanol, aqueous, and the combined aqueous and ethanol extracts (synergetic effect) of the <em>Bergenia ligulata </em>leaves.</p> <p><strong>Results: </strong>The zone of inhibition ranged from 6.93 ±0.02<strong><sup>b</sup></strong> mm to 12.81 ±0.03<strong><sup>a</sup></strong> mm with <em>Escherichia coli</em> being the most susceptible at 12.81 ±0.03<strong><sup>a</sup></strong> mm to the ethanol and 11.53 ±0.02<strong><sup>a</sup></strong> mm to the aqueous extracts at 250 mg/ml concentration while <em>P. aeruginosa </em>and<em> Penicillin </em>spp. were the slightest susceptible at 10.88 ±0.02<sup>a</sup> mm to the ethanol and 09.76 ±0.02<sup>a</sup> mm to the aqueous extract at 250 mg/ml concentration. The control/standard antimicrobial agent (<em>Gentamicin</em> and <em>Metronidazole</em>) exhibited higher inhibitory activity than the plant extracts. The least inhibitory value of 6.25 mg/ml was produced against <em>P. aeruginosa </em>by the ethanolic extract and against<em> C. albicans</em> by the combined (aqueous and ethanol) extracts of the plant. The qualitative and quantitative phytochemical screening of the leaves of <em>Bergenia ligulata </em>reveals the presence of flavonoids, tannins, saponins, alkaloids, and steroids. The most abundant percentage composition observed was flavonoids (7.72%) while tannins had the least component (4.29%).</p> <p><strong>Conclusion: </strong>The findings from this study show that the leaves extracts hold considerable antimicrobial activity against commonly encountered microorganisms in the environment. This therefore, implies that it can be used as a chemotherapeutic agent which will contribute to the development of antibiotic drugs against the test organisms.</p> PRAGATI KUMAR, PRANAY WAL, AWANI KUMAR RAI, YATENDRA SINGH, SHASHI PRATAP SINGH Copyright (c) 2022 Pragati Kumar Sat, 16 Jul 2022 00:00:00 +0530